{"id":57,"date":"2020-02-20T14:33:43","date_gmt":"2020-02-20T13:33:43","guid":{"rendered":"https:\/\/ibba.cnr.it\/?page_id=57"},"modified":"2026-10-15T23:53:22","modified_gmt":"2026-10-15T21:53:22","slug":"biocel-biologia-cellulare-e-strutturale","status":"publish","type":"page","link":"https:\/\/ibba.cnr.it\/en\/ricerca\/biocel-biologia-cellulare-e-strutturale\/","title":{"rendered":"BIOCEL: Cellular and structural biology"},"content":{"rendered":"<p>This research line investigates the fundamental mechanisms by which cells organize, fold, modify, transport, and maintain proteins and macromolecular complexes within different subcellular compartments. Particular attention is given to processes occurring in the endoplasmic reticulum, protein quality control, intracellular trafficking, protein\u2013protein interactions, and the relationship between three-dimensional structure and biological function.<\/p>\n<p>The activities address these mechanisms across different organisms, from plant to animal and microbial systems, with the aim of identifying general cellular principles governing the biosynthesis of complex proteins, photosynthesis, seed storage protein synthesis, and the function of proteins of biomedical relevance.<\/p>\n<p>Research integrates\u00a0<em>in vivo<\/em>,\u00a0<em>in cellula<\/em>,\u00a0<em>in vitro<\/em>, and\u00a0<em>in silico<\/em>\u00a0approaches, combining cell biology, biochemistry, biophysics, and structural biology (cryo-EM, X-ray crystallography, and computational modelling) to elucidate the link between subcellular organization, molecular structure, and physiological function, with applications in biotechnology, agri-food science, and biomedicine.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This research line investigates the fundamental mechanisms by which cells organize, fold, modify, transport, and maintain proteins and macromolecular complexes within different subcellular compartments. Particular attention is given to processes occurring in the endoplasmic reticulum, protein quality control, intracellular trafficking, protein\u2013protein interactions, and the relationship between three-dimensional structure and biological function. The activities address these [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":880,"parent":23,"menu_order":16,"comment_status":"closed","ping_status":"closed","template":"page-template-ricerca.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-57","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>BIOCEL: Cellular and structural biology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibba.cnr.it\/en\/ricerca\/biocel-biologia-cellulare-e-strutturale\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:locale:alternate\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BIOCEL: Cellular and structural biology\" \/>\n<meta property=\"og:description\" content=\"This research line investigates the fundamental mechanisms by which cells organize, fold, modify, transport, and maintain proteins and macromolecular complexes within different subcellular compartments. 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