StaffPaola Cremonesi


Informations



E-mail
cremonesi@ibba.cnr.it

Phone
+39 03714662508

Office
Lodi

Research area
QUALY, BIOGEN


ORCID: 000-0002-8239-5549
Google Scholar: Profile
Research Gate: Paola Cremonesi
Scopus Author ID: 56212635100
WoS Researcher ID: C-2846-2015
Linkedin: Paola Cremonesi

Cremonesi Paola

Researcher

Education

2004: Ph.D. in Molecular Medicine (Genomics, Proteomics and Correlated Technologies) at University of Milan (Milan, Italy)

1998: Licensing of professional biologist

1997: Graduated Degree in Biology at the University of Milan (Milan, Italy)

Professional experience

2010-Present: Researcher at Italian National Research Council, Institute of Agricultural Biology and Biotechnology (IBBA-CNR), Lodi

2009-2010: Researcher with temporary position at Italian National Research Council, Institute of Agricultural Biology and Biotechnology (IBBA-CNR), Lodi

2007-2008: Fellowship at Italian National Research Council, Institute of Agricultural Biology and Biotechnology (IBBA-CNR)

2005-2006: Fellowship at University of Milan, Department of Biomedical Sciences and Technology

Research interests

  • Microbiology, Genomics, Transcriptomics, and Metagenomics for food quality and safety, animal health, and environmental analysis especially developing methods for microbial and pathogens detection and characterization.

Projects in progress

MITICAL - Improvement of the cultivation and production of industrial hemp in Lombardy through innovative cultivation techniques
Start date: 01/07/2020   End date: 30/06/2023

Regione Lombardia

Milano, Lodi, Roma
Monica Mattana

Project duration:
01/07/2020 - 30/06/2023
Financing body:
Regione Lombardia
Project research leader:
Monica Mattana
Headquarters:
Milano, Lodi, Roma

MITICAL - Improvement of the cultivation and production of industrial hemp in Lombardy through innovative cultivation techniques


The MITICAL project aims to deepen knowlege on industrial hemp culture, focusing on the final use of two main products: seeds and flowers. The project will be based on the following activities:

  • analysis of 4 hemp varieties, two monoecius and two dioecious, cultivated in two different pedoclimaticzones in Lombardy region,
  • evaluation of the agronomic performances after different growing condition: control, biostimulant treatment, elicitor treatment,
  • seeds:evaluation of nutritional quality by measuring protein and oil content, fatty acid profile and antinutritional compound content,
  • flowers: evaluation of secondary metabolites content (CBD, THC,) and other polyphenols,
  • study of transcriptome: correlation analysis between gene expression and phenotype/metabolite, identification of allelic polymorphism (SNP) and coexpression network,
  • metagenomic analysis of soil: characterization of fungi, bacteria, metazoa, before and after hemp cultivation.

The project will be hold with the collaboration of agrofarms belonging to the two lombard agriculture districts and the results obtained on seeds will be viable for feed and food industries whereas those on flowers for pharma and cosmetic sector.

sPATIALS3 - Improvement of agrifood productions and innovative technologies for a safer and more secure and sustainable nutrition
Start date: 01/02/2020   End date: 31/07/2022

Regione Lombardia

Milano, Lodi   Website

Francesca Sparvoli

Project duration:
01/02/2020 - 31/07/2022
Financing body:
Regione Lombardia
Project research leader:
Francesca Sparvoli
Headquarters:
Milano, Lodi
Project website:
Website

sPATIALS3 - Improvement of agrifood productions and innovative technologies for a safer and more secure and sustainable nutrition


sPATIALS3 is a technological and research hub involving 12 CNR Institutes belonging to 4 different Departments and 4 companies. Main objectives will be: obtainment of innovative food products improved for their nutritional and functional properties; provision and implementation of precision technologies to guarantee products quality, safety and traceability; development of innovative and eco-sustainable smart– and active-packaging to minimize and reuse wastes, where possible, and to increase food preservability; provision to consumers and producers of tools for results exploitation.

USEFUL - Development of techniques and supply chain processes (farms and dairies) to optimize environmental, territorial and managerial factors aimed at obtaining greater production efficiency and qualitative excellence in the production of DOP and typical cheeses
Start date: 18/12/2019   End date: 17/12/2022

Regione Lombardia

Lodi
Bianca Castiglioni

Project duration:
18/12/2019 - 17/12/2022
Financing body:
Regione Lombardia
Project research leader:
Bianca Castiglioni
Headquarters:
Lodi

USEFUL - Development of techniques and supply chain processes (farms and dairies) to optimize environmental, territorial and managerial factors aimed at obtaining greater production efficiency and qualitative excellence in the production of DOP and typical cheeses


The USEFUL project aims to solve some critical issues in the production of Lombardy PDO cheeses (Grana Padano and Taleggio) in order to guarantee the competitiveness of the agro-industry companies. To this end, supply chain strategies and operational tools will be developed that allow to improve the microbiological and cheese-making quality of the milk and to improve all the cheese-making processes. These objectives will be achieved through the integration of the 3 sub-projects: Coordination, Innovation and Technological Transfer.

The expected results are: 1) to identify new procedures to improve animal health, food safety and the microbiological quality and cheese-making properties of milk; 2) to identify innovative procedures and operational tools to be used in the dairy industry to monitor the cheese-making and maturing phases of the cheese; 3) to define guidelines, technical manuals and fact sheets on the various procedures and techniques.

Projects completed

COVES - Development and validation of a rapid method for the detection of SARSCoV-2 on environmental surfaces
Start date: 21/04/2020   End date: 20/10/2020

Regione Lombardia

Lodi
Paola Cremonesi

Project duration:
21/04/2020 - 20/10/2020
Financing body:
Regione Lombardia
Project research leader:
Paola Cremonesi
Headquarters:
Lodi

COVES - Development and validation of a rapid method for the detection of SARSCoV-2 on environmental surfaces


The COVES project will develop and validate a simplified sampling and analysis procedure on a portable device for the specific and sensitive detection of the SARS-CoV-2 virus in the environment. This procedure will ensure greater safety in the work areas, thus reducing the negative impact that the COVID-19 emergency has on the local and national economy and decreasing the gap between the information and the suggested solutions. The main result of the project will be the development of a method for the rapid analysis of the SARS-CoV-2 in the environment, suitable for a field-use also by non-expert users. The project involves Hyris Ltd, leader of the project, which develops the technology, IBBA CNR which will take charge of the method validations and IZSLER (section of Pavia) which will validate “in-situ” the efficacy of this method on various contaminated surfaces using SARS-CoV-2 positive samples with known concentration.

BILLBOARDADVERTISING PLATE POSTER

DNA analysis using a low-cost portable device for food safety
Start date: 13/02/2019   End date: 12/06/2019

Hyris Ltd

Lodi   Website

Bianca Castiglioni

Project duration:
13/02/2019 - 12/06/2019
Financing body:
Hyris Ltd
Project research leader:
Bianca Castiglioni
Headquarters:
Lodi
Project website:
Website

DNA analysis using a low-cost portable device for food safety


The objective of this project is the development of new specific molecular methods for pathogen detection along the dairy supply chain, in order to overcome the critical issues related to field sample analysis. In particular, within this project Hyris Ltd intends to implement on its platform new Real-Time PCR protocols for analyzing dairy products, in order to detect the presence of pathogens responsible for toxic infections along the production chain.
FilAgro – Innovative and sustainable strategies for the agri-food chain
Start date: 05/08/2013   End date: 31/10/2015

Regione Lombardia

Milano, Lodi
Diego Breviario

Project duration:
05/08/2013 - 31/10/2015
Financing body:
Regione Lombardia
Project research leader:
Diego Breviario
Headquarters:
Milano, Lodi

FilAgro – Innovative and sustainable strategies for the agri-food chain


The FILAGRO project aims to provide solutions to several issues that are emerging in the field of modern agriculture. They concern: production sustainability, biodiversity and environment preservation; improvement in food quality, safety and healthy and nutritional aspects; technology development in favor of industry; new knowledge dissemination. These issues are highlighted as of high importance in the EXPO 2015 and Horizon 2020 programs as well as in the 2013-2015 plan of the Agriculture Directorate of the Lombardy Region.

GENOBU - Water buffalo genome sequencing for the quali-quantitative improvement of agrifood productions
Start date: 01/01/2019   End date: 31/12/2021

MIUR

Lodi
Bianca Castiglioni

Project duration:
01/01/2019 - 31/12/2021
Financing body:
MIUR
Project research leader:
Bianca Castiglioni
Headquarters:
Lodi

GENOBU - Water buffalo genome sequencing for the quali-quantitative improvement of agrifood productions


GENOBU is an original, innovative and multidisciplinary project combining genome sequencing of the water buffalo to the healthiness of animals and the improvement of quality and quantity of buffalo food products. The project will develop know-how and innovative process technologies to be provided to breeders and agro-food industry, with the objectives of optimizing the efficiency in milk processing, and to ensure best nutraceutical value to buffalo foods.

ANAFI - Analysis of genetic variability and haplotype at protein milks loci aimed at protecting biodiversity and producing diversified milks
Start date: 06/12/2017   End date: 05/12/2019

Associazione Nazionale Allevatori di bovini della razza Frisona Italiana (ANAFI)

Lodi   Website

Paola Cremonesi

Project duration:
06/12/2017 - 05/12/2019
Financing body:
Associazione Nazionale Allevatori di bovini della razza Frisona Italiana (ANAFI)
Project research leader:
Paola Cremonesi
Headquarters:
Lodi
Project website:
Website

ANAFI - Analysis of genetic variability and haplotype at protein milks loci aimed at protecting biodiversity and producing diversified milks


The objective of this project was to analyse how the frequencies of the main casein variants and haplotypes changed in the Italian Holstein breed, and the possible effects on milk technological properties (milks more suitable for dairy processing, with potential greater digestibility). The results obtained by the genotyping (Illumina beadchip) of all the historical data available (over 220,000 Italian Holstein Friesian individuals and over 600 Italian Jersey individuals) were analysed in order to verify how the allele frequencies to the casein genes have been changing in recent years. The results indicate that the increase of the B allele, favourable for cheese-making, and the decrease of the unfavourable E allele at the k-casein are compensating the increase of the A 2 allele at the β-casein, generally maintaining a good proportion of haplotypes associated with good cheese-making properties.

RABoLa - Sustainable strategies to reduce the use of antibiotics in dairy farming
Start date: 28/12/2018   End date: 27/12/2021

Regione Lombardia

Milano, Lodi   Website

Paola Cremonesi, Laura Morello

Project duration:
28/12/2018 - 27/12/2021
Financing body:
Regione Lombardia
Project research leader:
Paola Cremonesi, Laura Morello
Headquarters:
Milano, Lodi
Project website:
Website

RABoLa - Sustainable strategies to reduce the use of antibiotics in dairy farming


The project, which involves different departments of the University of Milan (DISAA, DIMEVET, VESPA), researchers from the CNR ISPA and CNR IBBA and the DIANA Department of the Catholic University of the Sacred Heart of Piacenza, aims the primary identification of operative practices for reducing the use of antibiotics in the dairy cow herds. During the study, operative protocols already preliminary tested (administration of Aloe arborescens, use of Lactococcus lactis subsp. cremoris in pre and post dipping, molecules to inhibit Prototheca spp) will be validated during the entire lactation cycle of the cows.

This project will allow breeders to take advantages of new nutraceutical strategies and alternatives to the use of antibiotics, to enhance the innate defences and reduce the incidence and severity of mastitis. The validation of an effective protocol for the selective drying of animals would lead to a reduction of the preventive use of antibiotics, in line with what is requested at European level.

Duck-Tech - Development of an integrated and sustainable system to produce bio-product: recycling of wastewater from ofmsw anaerobic digestion
Start date: 02/05/2015   End date: 30/04/2018

Fondazione Cariplo

Milano, Lodi   Website

Bianca Castiglioni

Project duration:
02/05/2015 - 30/04/2018
Financing body:
Fondazione Cariplo
Project research leader:
Bianca Castiglioni
Headquarters:
Milano, Lodi
Project website:
Website

Duck-Tech - Development of an integrated and sustainable system to produce bio-product: recycling of wastewater from ofmsw anaerobic digestion


The purpose of the project is to develop an integrated biological system to purify wastewater originated by anaerobic digestion of OFSMW, based on duckweed ability to tolerate high nitrogen and phosphorous concentration.

The project is proposing to develop a sustainable and completely natural system capable of achieving two objectives at the same time:

– a biological wastewater treatment;

– the transformation of some pollutants in raw materials (starch and fatty acids) that can be used in food and biochemical industries , replacing products obtained from agriculture or hydrocarbons.

In addition we would like to make a contribution to the understanding of microbiome degrading in the rhizosphere of aquatic plants used in the system, highlighting its effects on urban organic waste purification and more broadly on microbial water safety.

FARM-INN Farm-level interventions supporting dairy industry innovation
Start date: 05/10/2020   End date: 31/08/2021

AGER

Lodi   Website

Bianca Castiglioni

Project duration:
05/10/2020 - 31/08/2021
Financing body:
AGER
Project research leader:
Bianca Castiglioni
Headquarters:
Lodi
Project website:
Website

FARM-INN Farm-level interventions supporting dairy industry innovation


The project FARM-INN aims to provide farm-level interventions supporting dairy industry enhancing safety and quality of milk and cheese and providing the necessary scientific evidence and new insight regarding their functional properties. The proposed actions will be carried out assessing and improving animal welfare and the environmental sustainability. In particular, two aspects will be tackled and studied in the proposed project: i) the development and use of new feed supplements adsorbing mycotoxins and reducing pathogenic and spoilage clostridia in milk ii) the characterization of cheese making and functional properties of A1 and A2 variants of beta-casein in milk. The evaluation of environmental sustainability of the adsorbent supplementations to the cow rations and the potential effect of cheese making using A1 and A2 beta-casein types in milk analyses through a Life Cycle Assessment approach will be performed.

The project will offer opportunities to the dairy farmers to strengthen their competitiveness, in the context of a better control of safety and quality issues, and will help dairy industry in placing on the market high-quality products adapted to the new expectations of consumers.

SAFE&SMART
Start date: 01/09/2013   End date: 31/07/2017

MIUR

Milano, Lodi   Website

Diego Breviario

Project duration:
01/09/2013 - 31/07/2017
Financing body:
MIUR
Project research leader:
Diego Breviario
Headquarters:
Milano, Lodi
Project website:
Website

SAFE&SMART


TBP (Tubulin –Based-Polymorphism) analyses of several wheat species and varieties of Triticum durum. Development of a panel of molecular probes suitable for wheat species recognition in food.
Istituto

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